T.B. Kepler
T.B. Kepler
Professor of Microbiology and Professor of Mathematics and Statistics
Verified email at
Cited by
Cited by
Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
HX Liao, R Lynch, T Zhou, F Gao, SM Alam, SD Boyd, AZ Fire, KM Roskin, ...
Nature 496 (7446), 469-476, 2013
Stochasticity in transcriptional regulation: origins, consequences, and mathematical representations
TB Kepler, TC Elston
Biophysical journal 81 (6), 3116-3136, 2001
Invertebrate immune systems–not homogeneous, not simple, not well understood
ES Loker, CM Adema, SM Zhang, TB Kepler
Immunological reviews 198 (1), 10-24, 2004
Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers.
S Han, K Hathcock, B Zheng, TB Kepler, R Hodes, G Kelsoe
Journal of immunology (Baltimore, Md.: 1950) 155 (2), 556-567, 1995
B-cell–lineage immunogen design in vaccine development with HIV-1 as a case study
BF Haynes, G Kelsoe, SC Harrison, TB Kepler
Nature biotechnology 30 (5), 423-433, 2012
Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors
M Bonsignori, KK Hwang, X Chen, CY Tsao, L Morris, E Gray, DJ Marshall, ...
Journal of virology 85 (19), 9998-10009, 2011
Classification of osteoarthritis biomarkers: a proposed approach
DC Bauer, DJ Hunter, SB Abramson, M Attur, M Corr, D Felson, ...
Osteoarthritis and Cartilage 14 (8), 723-727, 2006
Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin
JRR Whittle, R Zhang, S Khurana, LR King, J Manischewitz, H Golding, ...
Proceedings of the National Academy of Sciences 108 (34), 14216-14221, 2011
Advantage of rare HLA supertype in HIV disease progression
E Trachtenberg, B Korber, C Sollars, TB Kepler, PT Hraber, E Hayes, ...
Nature medicine 9 (7), 928-935, 2003
Diversification of Ig superfamily genes in an invertebrate
SM Zhang, CM Adema, TB Kepler, ES Loker
Science 305 (5681), 251-254, 2004
Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2
HX Liao, M Bonsignori, SM Alam, JS McLellan, GD Tomaras, MA Moody, ...
Immunity 38 (1), 176-186, 2013
Pathway level analysis of gene expression using singular value decomposition
J Tomfohr, J Lu, TB Kepler
BMC bioinformatics 6, 1-11, 2005
A model of large-scale proteome evolution
RV Solé, R Pastor-Satorras, E Smith, TB Kepler
Advances in Complex Systems 5 (01), 43-54, 2002
Cyclic re-entry of germinal center B cells and the efficiency of affinity maturation
TB Kepler, AS Perelson
Immunology today 14 (8), 412-415, 1993
The T helper type 2 response to cysteine proteases requires dendritic cell–basophil cooperation via ROS-mediated signaling
H Tang, W Cao, SP Kasturi, R Ravindran, HI Nakaya, K Kundu, N Murthy, ...
Nature immunology 11 (7), 608-617, 2010
Maturation pathway from germline to broad HIV-1 neutralizer of a CD4-mimic antibody
M Bonsignori, T Zhou, Z Sheng, L Chen, F Gao, MG Joyce, G Ozorowski, ...
Cell 165 (2), 449-463, 2016
Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies
F Gao, M Bonsignori, HX Liao, A Kumar, SM Xia, X Lu, F Cai, KK Hwang, ...
Cell 158 (3), 481-491, 2014
Microbial colonization influences early B-lineage development in the gut lamina propria
DR Wesemann, AJ Portuguese, RM Meyers, MP Gallagher, K Cluff-Jones, ...
Nature 501 (7465), 112-115, 2013
Drug concentration heterogeneity facilitates the evolution of drug resistance
TB Kepler, AS Perelson
Proceedings of the National Academy of Sciences 95 (20), 11514-11519, 1998
Complex antigens drive permissive clonal selection in germinal centers
M Kuraoka, AG Schmidt, T Nojima, F Feng, A Watanabe, D Kitamura, ...
Immunity 44 (3), 542-552, 2016
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