| Discovery of a chemical probe bisamide (CCT251236): an orally bioavailable efficacious pirin ligand from a heat shock transcription factor 1 (HSF1) phenotypic screen MD Cheeseman, NEA Chessum, CS Rye, AE Pasqua, MJ Tucker, ... Journal of medicinal chemistry 60 (1), 180-201, 2017 | 50 | 2017 |
| Discovery of a chemical probe bisamide (CCT251236): an orally bioavailable efficacious pirin ligand from a heat shock transcription factor 1 (HSF1) phenotypic screen MD Cheeseman, NEA Chessum, CS Rye, AE Pasqua, MJ Tucker, ... Journal of medicinal chemistry 60 (1), 180-201, 2017 | 50 | 2017 |
| Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach P Innocenti, HL Woodward, S Solanki, S Naud, IM Westwood, N Cronin, ... Journal of medicinal chemistry 59 (8), 3671-3688, 2016 | 34 | 2016 |
| Quantitative analysis of influenza virus RNP interaction with RNA cap structures and comparison to human cap binding protein eIF4E L Hooker, R Sully, B Handa, N Ono, H Koyano, K Klumpp Biochemistry 42 (20), 6234-6240, 2003 | 32 | 2003 |
| Introduction of a Methyl Group Curbs Metabolism of Pyrido [3, 4-d] pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate … HL Woodward, P Innocenti, KMJ Cheung, A Hayes, J Roberts, AT Henley, ... Journal of Medicinal Chemistry 61 (18), 8226-8240, 2018 | 29 | 2018 |
| Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy A Faisal, GWY Mak, MD Gurden, CPR Xavier, SJ Anderhub, P Innocenti, ... British journal of cancer 116 (9), 1166-1176, 2017 | 27 | 2017 |
| Discovery of 4, 6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9 CS Rye, NEA Chessum, S Lamont, KG Pike, P Faulder, J Demeritt, ... Medchemcomm 7 (8), 1580-1586, 2016 | 23 | 2016 |
| Expanding the scope of fused pyrimidines as kinase inhibitor scaffolds: synthesis and modification of pyrido [3, 4-d] pyrimidines P Innocenti, H Woodward, L O'Fee, S Hoelder Organic & biomolecular chemistry 13 (3), 893-904, 2015 | 23 | 2015 |
| Privileged structures and polypharmacology within and between protein families J Meyers, NEA Chessum, S Ali, NY Mok, B Wilding, AE Pasqua, ... ACS Medicinal Chemistry Letters 9 (12), 1199-1204, 2018 | 19 | 2018 |
| 7-(Pyrazol-4-yl)-3H-imidazo [4, 5-b] pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation … V Bavetsias, Y Pérez-Fuertes, PJ McIntyre, B Atrash, M Kosmopoulou, ... Bioorganic & Medicinal Chemistry Letters 25 (19), 4203-4209, 2015 | 18 | 2015 |
| Influenza virus endoribonuclease K Klumpp, L Hooker, B Handa Methods in Enzymology 342, 451-466, 2001 | 18 | 2001 |
| A sensitive, single-tube assay to measure the enzymatic activities of influenza RNA polymerase and other poly (A) polymerases: application to kinetic and inhibitor analysis L Hooker, R Strong, R Adams, B Handa, JH Merrett, JA Martin, K Klumpp Nucleic acids research 29 (13), 2691-2698, 2001 | 17 | 2001 |
| In vitro and in vivo profile of the preclinical candidate and MPS1 kinase inhibitor CCT289346 H Woodward, P Innocenti, KMJ Cheung, S Naud, A Faisal, GW Mak, ... Cancer Research 78 (13_Supplement), 1651-1651, 2018 | | 2018 |
| Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen MD Cheeseman, NE Chessum, CS Rye, EA Pasqua, MJ Tucker, ... Cancer Research 77 (13_Supplement), LB-304-LB-304, 2017 | | 2017 |
| Induction of detrimental aneuploidy in basal breast cancer cells treated by MPS1 inhibitors in combination with paclitaxel SJ Anderhub, GWY Mak, A Faisal, K Walsh, M Gurden, L Day, P Innocenti, ... Cancer Research 77 (13_Supplement), 4036-4036, 2017 | | 2017 |
| Inhibitors of MPS1: Discovery of CCT289346, a highly potent, selective and orally available preclinical candidate HL Woodward, P Innocenti, KMJ Cheung, S Naud, A Hayes, AT Henley, ... Cancer Research 77 (13_Supplement), 193-193, 2017 | | 2017 |
| Discovery of CCT251236 from an HSF1 phenotypic screen: A pirin ligand with efficacy in an ovarian adenocarcinoma model E Pasqua, M Cheeseman, N Chessum, C Rye, M Tucker, B Wilding, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 253, 2017 | | 2017 |
| Correction: Discovery of 4, 6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9. See CS Rye, NEA Chessum, S Lamont, KG Pike, P Faulder, J Demeritt, ... MedChemComm 7 (9), 1870-1870, 2016 | | 2016 |
