Lisa (Hooker) O'Fee
Lisa (Hooker) O'Fee
Verified email at icr.ac.uk
Title
Cited by
Cited by
Year
Quantitative analysis of influenza virus RNP interaction with RNA cap structures and comparison to human cap binding protein eIF4E
L Hooker, R Sully, B Handa, N Ono, H Koyano, K Klumpp
Biochemistry 42 (20), 6234-6240, 2003
282003
Discovery of a chemical probe bisamide (CCT251236): an orally bioavailable efficacious pirin ligand from a heat shock transcription factor 1 (HSF1) phenotypic screen
MD Cheeseman, NEA Chessum, CS Rye, AE Pasqua, MJ Tucker, ...
Journal of medicinal chemistry 60 (1), 180-201, 2017
252017
Discovery of a chemical probe bisamide (CCT251236): an orally bioavailable efficacious pirin ligand from a heat shock transcription factor 1 (HSF1) phenotypic screen
MD Cheeseman, NEA Chessum, CS Rye, AE Pasqua, MJ Tucker, ...
Journal of medicinal chemistry 60 (1), 180-201, 2017
252017
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy
A Faisal, GWY Mak, MD Gurden, CPR Xavier, SJ Anderhub, P Innocenti, ...
British journal of cancer 116 (9), 1166-1176, 2017
192017
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach
P Innocenti, HL Woodward, S Solanki, S Naud, IM Westwood, N Cronin, ...
Journal of medicinal chemistry 59 (8), 3671-3688, 2016
182016
Influenza virus endoribonuclease
K Klumpp, L Hooker, B Handa
Methods in enzymology 342, 451-466, 2001
162001
Discovery of 4, 6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9
CS Rye, NEA Chessum, S Lamont, KG Pike, P Faulder, J Demeritt, ...
Medchemcomm 7 (8), 1580-1586, 2016
152016
A sensitive, single-tube assay to measure the enzymatic activities of influenza RNA polymerase and other poly (A) polymerases: application to kinetic and inhibitor analysis
L Hooker, R Strong, R Adams, B Handa, JH Merrett, JA Martin, K Klumpp
Nucleic acids research 29 (13), 2691-2698, 2001
142001
7-(Pyrazol-4-yl)-3H-imidazo [4, 5-b] pyridine-based derivatives for kinase inhibition: Co-crystallisation studies with Aurora-A reveal distinct differences in the orientation …
V Bavetsias, Y Pérez-Fuertes, PJ McIntyre, B Atrash, M Kosmopoulou, ...
Bioorganic & medicinal chemistry letters 25 (19), 4203-4209, 2015
132015
Expanding the scope of fused pyrimidines as kinase inhibitor scaffolds: synthesis and modification of pyrido [3, 4-d] pyrimidines
P Innocenti, H Woodward, L O'Fee, S Hoelder
Organic & biomolecular chemistry 13 (3), 893-904, 2015
122015
Privileged structures and polypharmacology within and between protein families
J Meyers, NEA Chessum, S Ali, NY Mok, B Wilding, AE Pasqua, ...
ACS medicinal chemistry letters 9 (12), 1199-1204, 2018
62018
Introduction of a Methyl Group Curbs Metabolism of Pyrido [3, 4-d] pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate …
HL Woodward, P Innocenti, KMJ Cheung, A Hayes, J Roberts, AT Henley, ...
Journal of medicinal chemistry 61 (18), 8226-8240, 2018
62018
In vitro and in vivo profile of the preclinical candidate and MPS1 kinase inhibitor CCT289346
H Woodward, P Innocenti, KMJ Cheung, S Naud, A Faisal, GW Mak, ...
Cancer Research 78 (13 Supplement), 1651-1651, 2018
2018
Abstract LB-304: Discovery of chemical probe CCT251236: An orally bioavailable efficacious pirin ligand from an HSF1 phenotypic screen
MD Cheeseman, NE Chessum, CS Rye, EA Pasqua, MJ Tucker, ...
Cancer Research 77 (13 Supplement), LB-304-LB-304, 2017
2017
Induction of detrimental aneuploidy in basal breast cancer cells treated by MPS1 inhibitors in combination with paclitaxel
SJ Anderhub, GWY Mak, A Faisal, K Walsh, M Gurden, L Day, P Innocenti, ...
Cancer Research 77 (13 Supplement), 4036-4036, 2017
2017
Inhibitors of MPS1: Discovery of CCT289346, a highly potent, selective and orally available preclinical candidate
HL Woodward, P Innocenti, KMJ Cheung, S Naud, A Hayes, AT Henley, ...
Cancer Research 77 (13 Supplement), 193-193, 2017
2017
Discovery of CCT251236 from an HSF1 phenotypic screen: A pirin ligand with efficacy in an ovarian adenocarcinoma model
E Pasqua, M Cheeseman, N Chessum, C Rye, M Tucker, B Wilding, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 253, 2017
2017
Correction: Discovery of 4, 6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9. See
CS Rye, NEA Chessum, S Lamont, KG Pike, P Faulder, J Demeritt, ...
MedChemComm 7 (9), 1870-1870, 2016
2016
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