| Discovery and resistance mechanism of a selective CDK12 degrader B Jiang, Y Gao, J Che, W Lu, IH Kaltheuner, R Dries, M Kalocsay, ... Nature chemical biology 17 (6), 675-683, 2021 | 79 | 2021 |
| Development of CDK2 and CDK5 dual degrader TMX‐2172 M Teng, J Jiang, Z He, NP Kwiatkowski, KA Donovan, CE Mills, C Victor, ... Angewandte Chemie 132 (33), 13969-13974, 2020 | 52 | 2020 |
| Exploring the target scope of KEAP1 E3 ligase-based PROTACs G Du, J Jiang, NJ Henning, N Safaee, E Koide, RP Nowak, KA Donovan, ... Cell chemical biology 29 (10), 1470-1481. e31, 2022 | 37 | 2022 |
| Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma B Jiang, J Jiang, IH Kaltheuner, AB Iniguez, K Anand, FM Ferguson, ... European Journal of Medicinal Chemistry 221, 113481, 2021 | 30 | 2021 |
| Discovery of a potent degrader for fibroblast growth factor receptor 1/2 G Du, J Jiang, Q Wu, NJ Henning, KA Donovan, H Yue, J Che, W Lu, ... Angewandte Chemie 133 (29), 16041-16047, 2021 | 30 | 2021 |
| Two new spirooxindole alkaloids from rhizosphere strain Streptomyces sp. xzqh-9 K Guo, T Fang, J Wang, A Wu, Y Wang, J Jiang, X Wu, S Song, W Su, ... Bioorganic & Medicinal Chemistry Letters 24 (21), 4995-4998, 2014 | 29 | 2014 |
| Targeting BRK-positive breast cancers with small-molecule kinase inhibitors J Jiang, F Gui, Z He, L Li, Y Li, S Li, X Wu, Z Deng, X Sun, X Huang, ... Cancer research 77 (1), 175-186, 2017 | 27 | 2017 |
| Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling M Fan, W Lu, J Che, NP Kwiatkowski, Y Gao, HS Seo, SB Ficarro, ... Elife 11, e78810, 2022 | 25 | 2022 |
| Structure-based design of a potent and selective covalent inhibitor for SRC kinase that targets a P-loop cysteine G Du, S Rao, D Gurbani, NJ Henning, J Jiang, J Che, A Yang, SB Ficarro, ... Journal of medicinal chemistry 63 (4), 1624-1641, 2020 | 24 | 2020 |
| A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant BtkC481S mutation in B‐cell malignancies F Gui, J Jiang, Z He, L Li, Y Li, Z Deng, Y Lu, X Wu, G Chen, J Su, S Song, ... British Journal of Pharmacology 176 (23), 4491-4509, 2019 | 17 | 2019 |
| A new ALK inhibitor overcomes resistance to first‐and second‐generation inhibitors in NSCLC Y Lu, Z Fan, SJ Zhu, X Huang, Z Zhuang, Y Li, Z Deng, L Gao, X Hong, ... EMBO molecular medicine 14 (1), e14296, 2022 | 15 | 2022 |
| Discovery of covalent MKK4/7 dual inhibitor J Jiang, B Jiang, Z He, SB Ficarro, J Che, JA Marto, Y Gao, T Zhang, ... Cell Chemical Biology 27 (12), 1553-1560. e8, 2020 | 12 | 2020 |
| Development of highly potent and selective pyrazolopyridine inhibitor of CDK8/19 JM Hatcher, PS Vatsan, E Wang, J Jiang, NS Gray ACS Medicinal Chemistry Letters 12 (11), 1689-1693, 2021 | 8 | 2021 |
| Exploring Ligand-Directed N-Acyl-N-alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development M Teng, J Jiang, SB Ficarro, HS Seo, JH Bae, KA Donovan, ES Fischer, ... ACS Medicinal Chemistry Letters 12 (8), 1302-1307, 2021 | 7 | 2021 |
| Development of potent and selective degraders of PI5P4Kγ W Ji, ES Wang, TD Manz, J Jiang, KA Donovan, X Abulaiti, ES Fischer, ... European Journal of Medicinal Chemistry 247, 115027, 2023 | 5 | 2023 |
| Selective macrocyclic inhibitors of DYRK1A/B CE Powell, JM Hatcher, J Jiang, PS Vatsan, J Che, NS Gray ACS Medicinal Chemistry Letters 13 (4), 577-585, 2022 | 4 | 2022 |
| Synthesis and Structure–Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold Z Li, R Ishida, Y Liu, J Wang, Y Li, Y Gao, J Jiang, J Che, JM Sheltzer, ... European journal of medicinal chemistry 238, 114433, 2022 | 3 | 2022 |
| Integrin α5 Is regulated by miR-218-5p in endothelial progenitor cells J Liu, Y Li, L Lyu, L Xiao, AA Memon, X Yu, A Halim, S Patel, A Osman, ... Journal of the American Society of Nephrology 33 (3), 565-582, 2022 | 3 | 2022 |
| Synthesis and structure-activity relationships of targeted protein degraders for the understudied kinase NEK9 SS Ryu, GE Gadbois, AJ Tao, BJ Fram, J Jiang, B Boyle, KA Donovan, ... Current Research in Chemical Biology 1, 100008, 2021 | 3 | 2021 |
| Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader M Teng, J Jiang, ES Wang, Q Geng, ST Toenjes, KA Donovan, N Mageed, ... Angewandte Chemie 135 (18), e202302364, 2023 | 2 | 2023 |
