jemeen sreedharan
jemeen sreedharan
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Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
C Vance, B Rogelj, T Hortobágyi, KJ De Vos, AL Nishimura, J Sreedharan, ...
Science 323 (5918), 1208-1211, 2009
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
J Sreedharan, IP Blair, VB Tripathi, X Hu, C Vance, B Rogelj, S Ackerley, ...
Science 319 (5870), 1668-1672, 2008
The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings
RW Paterson, RL Brown, L Benjamin, R Nortley, S Wiethoff, T Bharucha, ...
Brain 143 (10), 3104-3120, 2020
Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis
NJ Rutherford, YJ Zhang, M Baker, JM Gass, NCA Finch, YF Xu, ...
PLoS genetics 4 (9), e1000193, 2008
Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13. 2–21.3
C Vance, A Al-Chalabi, D Ruddy, BN Smith, X Hu, J Sreedharan, ...
Brain 129 (4), 868-876, 2006
Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age-and dose-dependent fashion
JC Mitchell, P McGoldrick, C Vance, T Hortobagyi, J Sreedharan, B Rogelj, ...
Acta neuropathologica 125, 273-288, 2013
Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
TM Miller, ME Cudkowicz, A Genge, PJ Shaw, G Sobue, RC Bucelli, ...
New England Journal of Medicine 387 (12), 1099-1110, 2022
TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD
MA White, E Kim, A Duffy, R Adalbert, BU Phillips, OM Peters, ...
Nature neuroscience 21 (4), 552-563, 2018
Amyotrophic lateral sclerosis: problems and prospects
J Sreedharan, RH Brown Jr
Annals of neurology 74 (3), 309-316, 2013
Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS
K Weskamp, EM Tank, R Miguez, JP McBride, NB Gómez, M White, Z Lin, ...
The Journal of clinical investigation 130 (3), 1139-1155, 2020
Age-dependent TDP-43-mediated motor neuron degeneration requires GSK3, hat-trick, and xmas-2
J Sreedharan, LJ Neukomm, RH Brown, MR Freeman
Current Biology 25 (16), 2130-2136, 2015
Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss
MA White, Z Lin, E Kim, CM Henstridge, E Pena Altamira, CK Hunt, ...
Acta neuropathologica communications 7 (1), 1-16, 2019
Amyotrophic lateral sclerosis: recent genetic highlights
MA White, J Sreedharan
Current opinion in neurology 29 (5), 557-564, 2016
Relative preservation of triceps over biceps strength in upper limb-onset ALS: The ‘split elbow’
R Khalaf, S Martin, C Ellis, R Burman, J Sreedharan, C Shaw, PN Leigh, ...
Journal of Neurology, Neurosurgery & Psychiatry 90 (7), 730-733, 2019
Predicting the future of ALS: the impact of demographic change and potential new treatments on the prevalence of ALS in the United Kingdom, 2020–2116
A Gowland, S Opie-Martin, KM Scott, AR Jones, PR Mehta, CJ Batts, ...
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration 20 (3-4), 264-274, 2019
Optimizing reproducibility of operant testing through reinforcer standardization: identification of key nutritional constituents determining reward strength in touchscreens
EW Kim, BU Phillips, CJ Heath, SY Cho, H Kim, J Sreedharan, HT Song, ...
Molecular brain 10 (1), 1-10, 2017
Alexander disease with hypothermia, microcoria, and psychiatric and endocrine disturbances
J Sreedharan, CE Shaw, J Jarosz, M Samuel
Neurology 68 (16), 1322-1323, 2007
Falsely pessimistic prognosis by EEG in post-anoxic coma after cardiac arrest: the borderland of nonconvulsive status epilepticus
J Sreedharan, E Gourlay, MR Evans, M Koutroumanidis
Epileptic Disorders 14, 340-344, 2012
Striking phenotypic variation in a family with the P506S UBQLN2 mutation including amyotrophic lateral sclerosis, spastic paraplegia, and frontotemporal dementia
SA Gkazi, C Troakes, S Topp, JW Miller, CA Vance, J Sreedharan, ...
Neurobiology of Aging 73, 229. e5-229. e9, 2019
Female sex mitigates motor and behavioural phenotypes in TDP-43Q331K knock-in mice
J Watkins, A Ghosh, AFA Keerie, JJP Alix, RJ Mead, J Sreedharan
Scientific Reports 10 (1), 19220, 2020
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