|Automated design of ligands to polypharmacological profiles|
J Besnard, GF Ruda, V Setola, K Abecassis, RM Rodriguiz, XP Huang, ...
Nature 492 (7428), 215-220, 2012
|N-myristoyltransferase inhibitors as new leads to treat sleeping sickness|
JA Frearson, S Brand, SP McElroy, LAT Cleghorn, O Smid, L Stojanovski, ...
Nature 464 (7289), 728-732, 2010
|A novel multiple-stage antimalarial agent that inhibits protein synthesis|
B Baragaña, I Hallyburton, MCS Lee, NR Norcross, R Grimaldi, TD Otto, ...
Nature 522 (7556), 315-320, 2015
|Lessons learnt from assembling screening libraries for drug discovery for neglected diseases|
R Brenk, A Schipani, D James, A Krasowski, IH Gilbert, J Frearson, ...
ChemMedChem 3 (3), 435, 2008
|Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need|
MC Field, D Horn, AH Fairlamb, MAJ Ferguson, DW Gray, KD Read, ...
Nature Reviews Microbiology 15 (4), 217-231, 2017
|Design and synthesis of a series of melamine-based nitroheterocycles with activity against trypanosomatid parasites|
A Baliani, GJ Bueno, ML Stewart, V Yardley, R Brun, MP Barrett, IH Gilbert
Journal of medicinal chemistry 48 (17), 5570-5579, 2005
|Drug discovery for neglected diseases: molecular target-based and phenotypic approaches: miniperspectives series on phenotypic screening for antiinfective targets|
Journal of medicinal chemistry 56 (20), 7719-7726, 2013
|Target assessment for antiparasitic drug discovery|
JA Frearson, PG Wyatt, IH Gilbert, AH Fairlamb
Trends in parasitology 23 (12), 589-595, 2007
|Synthesis and biological evaluation of s-triazine substituted polyamines as potential new anti-trypanosomal drugs|
B Klenke, M Stewart, MP Barrett, R Brun, IH Gilbert
Journal of medicinal chemistry 44 (21), 3440-3452, 2001
|Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes|
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1587 (2-3 …, 2002
|Screening Congo Red and its analogues for their ability to prevent the formation of PrP-res in scrapie-infected cells|
H Rudyk, S Vasiljevic, RM Hennion, CR Birkett, J Hope, IH Gilbert
Journal of General Virology 81 (4), 1155-1164, 2000
|Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay|
M De Rycker, I Hallyburton, J Thomas, L Campbell, S Wyllie, D Joshi, ...
Antimicrobial agents and chemotherapy 57 (7), 2913-2922, 2013
|Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein …|
S Patterson, MS Alphey, DC Jones, EJ Shanks, IP Street, JA Frearson, ...
Journal of medicinal chemistry 54 (19), 6514-6530, 2011
|Fragment-based hit identification: thinking in 3D|
AD Morley, A Pugliese, K Birchall, J Bower, P Brennan, N Brown, ...
Drug Discovery Today 18 (23-24), 1221-1227, 2013
|dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors|
JL Whittingham, I Leal, C Nguyen, G Kasinathan, E Bell, AF Jones, ...
Structure 13 (2), 329-338, 2005
|Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis|
SO Lorente, JCF Rodrigues, CJ Jiménez, M Joyce-Menekse, C Rodrigues, ...
Antimicrobial Agents and Chemotherapy 48 (8), 2937-2950, 2004
|Azasterols as Inhibitors of Sterol 24-Methyltransferase in Leishmania Species and Trypanosoma cruzi|
F Magaraci, CJ Jimenez, C Rodrigues, JCF Rodrigues, MV Braga, ...
Journal of medicinal chemistry 46 (22), 4714-4727, 2003
|Target validation: linking target and chemical properties to desired product profile|
P G Wyatt, I H Gilbert, K D Read, A H Fairlamb
Current topics in medicinal chemistry 11 (10), 1275-1283, 2011
|Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors|
S Brand, LAT Cleghorn, SP McElroy, DA Robinson, VC Smith, ...
Journal of medicinal chemistry 55 (1), 140-152, 2012
|Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase|
SF Chowdhury, VB Villamor, RH Guerrero, I Leal, R Brun, SL Croft, ...
Journal of medicinal chemistry 42 (21), 4300-4312, 1999