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Frances Sharom
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Year
ABC multidrug transporters: structure, function and role in chemoresistance
FJ Sharom
Future Medicine Ltd 9 (1), 105-127, 2008
12122008
ABC efflux pump-based resistance to chemotherapy drugs
PDW Eckford, FJ Sharom
Chemical reviews 109 (7), 2989-3011, 2009
6742009
The P-glycoprotein multidrug transporter
FJ Sharom
Essays in biochemistry 50, 161-178, 2011
5992011
The P-glycoprotein efflux pump: how does it transport drugs?
FJ Sharom
The Journal of membrane biology 160, 161-175, 1997
5771997
β‐Amyloid efflux mediated by p‐glycoprotein
FC Lam, R Liu, P Lu, AB Shapiro, JM Renoir, FJ Sharom, PB Reiner
Journal of neurochemistry 76 (4), 1121-1128, 2001
5092001
Complex interplay between the P-glycoprotein multidrug efflux pump and the membrane: its role in modulating protein function
FJ Sharom
Frontiers in oncology 4, 41, 2014
3112014
Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein.
FJ Sharom, X Yu, CA Doige
Journal of Biological Chemistry 268 (32), 24197-24202, 1993
3021993
The membrane lipid environment modulates drug interactions with the P-glycoprotein multidrug transporter
Y Romsicki, FJ Sharom
Biochemistry 38 (21), 6887-6896, 1999
2891999
A model for ganglioside behaviour in cell membranes
FJ Sharom, CWM Grant
Biochimica et Biophysica Acta (BBA)-Biomembranes 507 (2), 280-293, 1978
2751978
Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells
FJ Sharom, X Yu, JWK Chu, CA Doige
Biochemical Journal 308 (2), 381-390, 1995
2621995
Site-directed fluorescence labeling of P-glycoprotein on cysteine residues in the nucleotide binding domains
R Liu, FJ Sharom
Biochemistry 35 (36), 11865-11873, 1996
2481996
The effects of lipids and detergents on ATPase-active P-glycoprotein
CA Doige, X Yu, FJ Sharom
Biochimica et Biophysica Acta (BBA)-Biomembranes 1146 (1), 65-72, 1993
2401993
Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter
Y Romsicki, FJ Sharom
Biochemistry 40 (23), 6937-6947, 2001
2152001
ATPase activity of partially purified P-glycoprotein from multidrug-resistant Chinese hamster ovary cells
CA Doige, X Yu, FJ Sharom
Biochimica et Biophysica Acta (BBA)-Biomembranes 1109 (2), 149-160, 1992
1991992
The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids
PDW Eckford, FJ Sharom
Biochemical Journal 389 (2), 517-526, 2005
1922005
Glycosylphosphatidylinositol-anchored proteins: structure, function, and cleavage by phosphatidylinositol-specific phospholipase C
FJ Sharom, MT Lehto
Biochemistry and cell biology 80 (5), 535-549, 2002
1782002
Multidrug resistance and chemosensitization: therapeutic implications for cancer chemotherapy
E Georges, FJ Sharom, V Ling
Advances in pharmacology 21, 185-220, 1990
1701990
Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1)
FJ Sharom
Biochemistry and cell biology 84 (6), 979-992, 2006
1512006
Interaction of LDS-751 with P-glycoprotein and mapping of the location of the R drug binding site
MR Lugo, FJ Sharom
Biochemistry 44 (2), 643-655, 2005
1502005
Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells
FJ Sharom, X Yu, P Lu, R Liu, JWK Chu, K Szabó, M Müller, CD Hose, ...
Biochemical pharmacology 58 (4), 571-586, 1999
1471999
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