A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS WYC Huang, S Alvarez, Y Kondo, YK Lee, JK Chung, HYM Lam, ... Science 363 (6431), 1098-1103, 2019 | 284 | 2019 |
Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5′ splice site recognition Y Kondo, C Oubridge, AMM van Roon, K Nagai elife 4, e04986, 2015 | 254 | 2015 |
Cryo-EM structure of a dimeric B-Raf: 14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases Y Kondo, J Ognjenović, S Banerjee, D Karandur, A Merk, K Kulhanek, ... Science 366 (6461), 109-115, 2019 | 135 | 2019 |
Deconstruction of the Ras switching cycle through saturation mutagenesis P Bandaru, NH Shah, M Bhattacharyya, JP Barton, Y Kondo, JC Cofsky, ... Elife 6, e27810, 2017 | 116 | 2017 |
Evolution of oligomeric state through allosteric pathways that mimic ligand binding T Perica, Y Kondo, SP Tiwari, SH McLaughlin, KR Kemplen, X Zhang, ... Science 346 (6216), 1254346, 2014 | 76 | 2014 |
The interdependent activation of Son-of-Sevenless and Ras P Bandaru, Y Kondo, J Kuriyan Cold Spring Harbor perspectives in medicine 9 (2), a031534, 2019 | 59 | 2019 |
Subunit disassembly and inhibition of TNFα by a semi-synthetic bicyclic peptide S Luzi, Y Kondo, E Bernard, LKJ Stadler, M Vaysburd, G Winter, ... Protein Engineering, Design & Selection 28 (2), 45-52, 2015 | 51 | 2015 |
Assembly and dynamics of the U4/U6 di-snRNP by single-molecule FRET JW Hardin, C Warnasooriya, Y Kondo, K Nagai, D Rueda Nucleic acids research 43 (22), 10963-10974, 2015 | 41 | 2015 |
A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1 Y Vercoulen, Y Kondo, JS Iwig, AB Janssen, KA White, M Amini, ... Elife 6, e29002, 2017 | 40 | 2017 |
A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane CW Lin, LM Nocka, BL Stinger, JB DeGrandchamp, LJN Lew, S Alvarez, ... Proceedings of the National Academy of Sciences 119 (19), e2122531119, 2022 | 33 | 2022 |
Chemical synthesis of U1 snRNA derivatives A Ohkubo, Y Kondo, M Suzuki, H Kobayashi, T Kanamori, Y Masaki, ... Organic letters 15 (17), 4386-4389, 2013 | 21 | 2013 |
Re-refinement of the spliceosomal U4 snRNP core-domain structure J Li, AK Leung, Y Kondo, C Oubridge, K Nagai Acta Crystallographica Section D: Structural Biology 72 (1), 131-146, 2016 | 19 | 2016 |
Relating cellular signaling timescales to single-molecule kinetics: A first-passage time analysis of Ras activation by SOS WYC Huang, S Alvarez, Y Kondo, J Kuriyan, JT Groves Proceedings of the National Academy of Sciences 118 (45), e2103598118, 2021 | 12 | 2021 |
Use of RNA tertiary interaction modules for the crystallisation of the spliceosomal snRNP core domain AKW Leung, C Kambach, Y Kondo, M Kampmann, M Jinek, K Nagai Journal of molecular biology 402 (1), 154-164, 2010 | 12 | 2010 |
New insights into Raf regulation from structural analyses Y Kondo, JW Paul III, S Subramaniam, J Kuriyan Current Opinion in Structural Biology 71, 223-231, 2021 | 6 | 2021 |
A two-component protein condensate of EGFR and Grb2 regulates Ras activation at the membrane CW Lin, LM Nocka, B Stinger, J DeGrandchamp, N Lew, S Alvarez, ... BioRxiv, 2021.12. 12.472247, 2021 | 3 | 2021 |
Engineering crystal packing in RNA-protein complexes II: a historical perspective from the structural studies of the spliceosome AKW Leung, Y Kondo, DAP Krummel, J Li, SR Price, AMM van Roon Crystals 11 (8), 948, 2021 | 2 | 2021 |
Molecular timing of membrane signaling reactions WYC Huang, S Alvarez, YK Lee, Y Kondo, JK Chung, HYM Lam, ... Biophysical Journal 114 (3), 202a, 2018 | 2 | 2018 |
A multi-reservoir extruder for time-resolved serial protein crystallography and compound screening at X-ray free-electron lasers M Wranik, MW Kepa, EV Beale, D James, Q Bertrand, T Weinert, A Furrer, ... Nature Communications 14 (1), 7956, 2023 | 1 | 2023 |
Photochemical affinity switches to resolve ligand dissociation from a G protein-coupled receptor by time-resolved serial crystallography J Standfuss, H Glover, T Sassmannshausen, Q Bertrand, M Trabuco, ... | | 2024 |